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التصنيف: vaccine
المادة الفعالة: bee venom

Bee Venom Vaccine (Apitoxin Immunotherapy)** is used in allergen-specific immunotherapy for patients with hypersensitivity to bee stings. It contains purified bee venom proteins (such as phospholipase A₂ and melittin) administered in gradually increasing doses to induce immune tolerance. The pharmacological action involves modulation of the immune response by shifting from an IgE-mediated allergic pathway toward a protective IgG₄ antibody response. This reduces mast cell and basophil activation upon future exposure to bee venom allergens. Clinically, it is indicated for prevention of severe systemic allergic reactions (anaphylaxis) in individuals with confirmed bee venom allergy.