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التصنيف: antineoplastic agent.cyclin-dependent kinase inhibitor
المادة الفعالة: palbociclib

palbociclib is a reversible small molecule cyclin-dependent kinase (cdk) inhibitor which is selective for cdk 4 and 6. cdks have a role in regulating progression through the cell cycle at the g1/s phase.
Mechanism of Action
Palbociclib is an oral, selective cyclin-dependent kinase (CDK) 4 and 6 inhibitor. It blocks CDK4/6-mediated phosphorylation of the retinoblastoma (Rb) protein, preventing progression from the G1 to S phase of the cell cycle. This results in cell-cycle arrest and inhibition of proliferation in Rb-positive cancer cells, particularly hormone receptor–positive breast cancer.