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Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic with strong activity against Gram-negative and some Gram-positive bacteria.
It works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs).
This leads to defective cell wall formation and ultimately bacterial cell lysis and death (bactericidal effect).
It has a long half-life, allowing once-daily dosing in many infections.
Indications include respiratory tract infections, urinary tract infections, sepsis, meningitis, and intra-abdominal infections.